Charlie catches a cold after he knowingly sleeps with a hot girl who is sick. Alan and Jake are on their way out and can't take care of Charlie. Berta can't be bothered. Desperate, Charlie calls his mom who is also unavailable. We see Rose, who was asked to leave England, climb over the deck. She steps up to the task and takes care of Charlie. Montage of Rose making Charlie soup, giving him a "special" pill that was just approved in England, cleaning him, bathing him, shaving him, dressing him. Rose makes sure he doesn't get out bed. Feeling a bit better Charlie gets himself up and makes it downstairs only to discover that he's been in bed for two weeks. Alan and Jake think it's great that Rose is taking care of him and they head out.
We go back upstairs and Rose is in the shower... we also see her clothes now neatly hanging in Charlie's closet. She comes out of the bathroom and tells him he needs to be back in bed sleeping and makes him take another pill. Charlie pretends to take the pill and go to sleep. After Rose leaves the room (she locks Charlie in) he takes the pill out and puts it under his pillow. He then proceeds to climb out the window down into Alan's bathroom (Alan is sitting on the toilet). Charlie tells Alan that he thinks Rose has been drugging him and he'll take him upstairs to show him the pill. We go upstairs and we see Berta out cold on Charlie's bed. Charlie has no proof.
The show's 100th episode ("City of Great Racks") aired on October 15, 2007. To celebrate this, a casino-inspired party was held at West Hollywood's Pacific Design Center. Warner Brothers Television also distributed blue Micargi Rover bicycles adorned with the Two and a Half Men logo along with the words 100 Episodes. Each bicycle came with a note saying "You've made us very proud. Here's to a long ride together." The cast also gifted the crew with sterling silver key rings from Tiffany & Co, the key rings were attached to small pendants with 100 and Two and a Half Men inscribed on either side of it.